crmPack: Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Version: 1.0.6
Depends: R (≥ 3.0.0), ggplot2 (≥ 2.0.0), graphics
Imports: methods, grid, gridExtra, GenSA, mvtnorm, parallel, rjags, utils, tools, MASS
Suggests: ggmcmc, knitr, Rcpp, RcppArmadillo
Published: 2024-06-26
DOI: 10.32614/CRAN.package.crmPack
Author: Daniel Sabanes Bove [aut, cre], Wai Yin Yeung [aut], Giuseppe Palermo [aut], Thomas Jaki [aut]
Maintainer: Daniel Sabanes Bove <daniel.sabanes_bove at>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright: F. Hoffmann-La Roche Ltd
NeedsCompilation: no
Citation: crmPack citation info
Materials: NEWS
In views: ClinicalTrials, ExperimentalDesign
CRAN checks: crmPack results


Reference manual: crmPack.pdf
Vignettes: Guidelines for developers and maintainer
crmPack: Object-oriented implementation of CRM designs


Package source: crmPack_1.0.6.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): crmPack_1.0.6.tgz, r-oldrel (arm64): crmPack_1.0.6.tgz, r-release (x86_64): crmPack_1.0.6.tgz, r-oldrel (x86_64): crmPack_1.0.6.tgz
Old sources: crmPack archive


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