DoseFinding: Planning and Analyzing Dose Finding Experiments

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

Version: 1.1-1
Depends: ggplot2, lattice, mvtnorm, R (≥ 2.15.0)
Suggests: numDeriv, Rsolnp, quadprog, parallel, multcomp, knitr, rmarkdown, MASS, testthat, RBesT
Published: 2023-11-02
DOI: 10.32614/CRAN.package.DoseFinding
Author: Bjoern Bornkamp ORCID iD [aut, cre], Jose Pinheiro [aut], Frank Bretz [aut], Ludger Sandig [aut], Marius Thomas [aut]
Maintainer: Bjoern Bornkamp <bjoern.bornkamp at>
License: GPL-3
NeedsCompilation: yes
Materials: ChangeLog
In views: ClinicalTrials, ExperimentalDesign
CRAN checks: DoseFinding results


Reference manual: DoseFinding.pdf
Vignettes: Analysis template MCP-Mod for continuous data
Design and analysis template MCP-Mod for binary data
Frequently Asked Questions for MCP-Mod
Analysis template: MCP-Mod with multiple regimen
Overview DoseFinding package
Sample size template for MCP-Mod for normally distributed data


Package source: DoseFinding_1.1-1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): DoseFinding_1.1-1.tgz, r-oldrel (arm64): DoseFinding_1.1-1.tgz, r-release (x86_64): DoseFinding_1.1-1.tgz, r-oldrel (x86_64): DoseFinding_1.1-1.tgz
Old sources: DoseFinding archive

Reverse dependencies:

Reverse depends: MCPModGeneral, TestingSimilarity
Reverse imports: BayesianMCPMod, clinDR, dosedesignR, LRcontrast, MCPModBC, uniReg
Reverse suggests: MCPModPack


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