BIGL: Biochemically Intuitive Generalized Loewe Model

Response surface methods for drug synergy analysis. Available methods include generalized and classical Loewe formulations as well as Highest Single Agent methodology. Response surfaces can be plotted in an interactive 3-D plot and formal statistical tests for presence of synergistic effects are available. Implemented methods and tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017) <doi:10.1038/s41598-017-18068-5>.

Version: 1.9.2
Depends: R (≥ 3.5)
Imports: ggplot2, MASS, methods, minpack.lm, numDeriv, parallel, progress, plotly, robustbase, scales, nleqslv, data.table, lifecycle
Suggests: knitr, rmarkdown, testthat, shiny, DT
Published: 2024-06-26
DOI: 10.32614/CRAN.package.BIGL
Author: Heather Turner, Annelies Tourny, Olivier Thas, Maxim Nazarov, Rytis Bagdziunas, Stijn Hawinkel, Javier Franco PĂ©rez, Kathy Mutambanengwe
Maintainer: Kathy Mutambanengwe <kathy.mutambanengwe at>
License: GPL-3
NeedsCompilation: no
Materials: NEWS
CRAN checks: BIGL results


Reference manual: BIGL.pdf
Vignettes: Synergy analysis


Package source: BIGL_1.9.2.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): BIGL_1.9.2.tgz, r-oldrel (arm64): BIGL_1.9.2.tgz, r-release (x86_64): BIGL_1.9.2.tgz, r-oldrel (x86_64): BIGL_1.9.2.tgz
Old sources: BIGL archive


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