ASSISTant: Adaptive Subgroup Selection in Group Sequential Trials

Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, <doi:10.1016/j.cct.2014.09.001>). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.

Version: 1.4.3
Imports: R6, mvtnorm, knitr, magrittr, dplyr
Suggests: rmarkdown
Published: 2022-12-02
DOI: 10.32614/CRAN.package.ASSISTant
Author: Tze Leung Lai [ctb], Philip Lavori [aut], Olivia Liao [aut], Balasubramanian Narasimhan [aut, cre], Ka Wai Tsang [aut]
Maintainer: Balasubramanian Narasimhan <naras at stat.Stanford.EDU>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Materials: README NEWS
CRAN checks: ASSISTant results


Reference manual: ASSISTant.pdf
Vignettes: Adaptive Subgroup Selection in Sequential Trials
Design of the DEFUSE3 Trial
Using Discrete Rankin Scores


Package source: ASSISTant_1.4.3.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): ASSISTant_1.4.3.tgz, r-oldrel (arm64): ASSISTant_1.4.3.tgz, r-release (x86_64): ASSISTant_1.4.3.tgz, r-oldrel (x86_64): ASSISTant_1.4.3.tgz
Old sources: ASSISTant archive


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