Extended Progression Models for Repeated Measures

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Documentation for package ‘progme’ version 0.1.0

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

adni_simulated	Simulated ADNI-style Alzheimer's trial data
biomarker_dosing_rule	Biomarker-informed adaptive dosing rule
check_convergence	Convergence checks
check_convergence.default	Convergence checks
default_priors	Default priors for Bayesian progression models
delayed_effect	Delayed treatment effect function
emax_biomarker	Emax biomarker model
find_sample_size	Find sample size by simulation
fit_pmrm	Unified estimation wrapper
goodness_of_fit	Goodness-of-fit summary
initialize_subjects	Initialize subjects for an adaptive trial simulation
parametric_bootstrap	Parametric bootstrap for confidence intervals
parkinsons_simulated	Simulated Parkinson's trial data with informative dropout
pkpd_concentration	PK/PD helpers for biomarker dosing
plot.pmrm_delayed	Plot a delayed-effect fit
pmrm_adaptive_trial	Run a biomarker-informed adaptive trial simulation
pmrm_competing	Fit a competing-risks progression model
pmrm_delayed	Fit a progression model with delayed treatment onset
pmrm_joint	Fit a joint longitudinal-survival model
pmrm_nlme	Fit a nonlinear progression mixed-effects model
population_trajectory	Population-level trajectory over a time grid
power_pmrm	Simulation-based power for progression trials
predict.pmrm_nlme	Predict from a fitted progression model
print.pmrm_delayed	Print method for delayed-effect fits
scenario_base	Scenario builders for trial simulation studies
scenario_optimistic	Scenario builders for trial simulation studies
scenario_pessimistic	Scenario builders for trial simulation studies
simulate_biomarker	Simulate biomarker measurements under the PK/PD model
simulate_joint_trial	Simulate a trial with informative dropout via a joint model mechanism
simulate_progression_trial	Simulate a progression trial
subject_summaries	Extract subject-level summary (EB intercept and slope)
summary.pmrm_competing	Summarize a competing-risks fit
summary.pmrm_delayed	Summarize a delayed-effect fit
summary.pmrm_joint	Summarize a joint model fit
to_event_data	Reshape long trial data to per-subject event data
vpc	Visual predictive check (VPC)