BOINTable               BOIN Decision Table for Dose-Finding Trials
ClopperPearsonCI        Clopper-Pearson Confidence Interval for
                        One-Sample Proportion
accrual                 Number of Enrolled Subjects
adaptDesign             Adaptive Design at an Interim Look
adaptDesign_multiarm    Adaptive Multi-Arm Multi-Stage Design
adaptDesign_seamless    Adaptive Phase 2/3 Seamless Design
aml                     Acute myelogenous leukemia survival data from
                        the survival package
assess_phregr           Assess Proportional Hazards Assumption Based on
                        Supremum Test
binary_tte_sim          Simulation for a Binary and a Time-to-Event
                        Endpoint in Group Sequential Trials
caltime                 Calendar Times for Target Number of Events
corr_pfs_os             Correlation Between PFS and OS Given
                        Correlation Between PD and OS
covrmst                 Covariance Between Restricted Mean Survival
                        Times
dtpwexp                 Density Function of Truncated Piecewise
                        Exponential Distribution
errorSpent              Error Spending
exitprob                Stagewise Exit Probabilities
exitprob_multiarm       Exit Probabilities for Multi-Arm Multi-Stage
                        Design
exitprob_seamless       Exit Probabilities for Phase 2/3 Seamless
                        Design
fCERCer                 Compute conditional error rates
fCERNewBound            Compute new stage-wise bounds after adaptation
fCERRej                 Determine stage 2 rejections from conditional
                        error rates
fCERStageBound          Compute stage-wise bounds for multiple testing
fDefaultWgtmat          Default Weight Matrix for All Intersection
                        Hypotheses
fPCRej                  Determine stage 2 rejections using p-value
                        combination
fPCStage1               Determine stage 1 rejections for adaptive
                        multiple testing
fPCStagewise            Compute stage-wise local p-values
fadjpbon                Adjusted p-Values for Bonferroni-Based
                        Graphical Approaches
fadjpdun                Adjusted p-Values for Dunnett-Based Graphical
                        Approaches
fadjpsim                Adjusted p-Values for Simes-Based Graphical
                        Approaches
finthyp                 Indicator Matrix for All Intersection
                        Hypotheses
float_to_fraction       Converting a decimal to a fraction
fmodmix                 Adjusted p-Values for Modified Mixture
                        Gatekeeping Procedures
fquantile               The Quantiles of a Survival Distribution
fseqbon                 Group Sequential Trials Using Bonferroni-Based
                        Graphical Approaches
fstdmix                 Adjusted p-Values for Standard Mixture
                        Gatekeeping Procedures
fstp2seq                Adjusted p-Values for Stepwise Testing
                        Procedures for Two Sequences
ftrunc                  Adjusted p-Values for Holm, Hochberg, and
                        Hommel Procedures
fwgtmat                 Weight Matrix for All Intersection Hypotheses
getADCI                 Confidence Interval After Adaptation
getADCI_multiarm        Confidence Interval After Adaptation for
                        Multi-Arm Multi-Stage Design
getADCI_seamless        Confidence Interval After Adaptation for Phase
                        2/3 Seamless Design
getADRCI                Repeated Confidence Interval After Adaptation
getAccrualDurationFromN
                        Accrual Duration to Enroll Target Number of
                        Subjects
getBound                Efficacy Boundaries for Group Sequential Design
getBound_multiarm       Efficacy Boundaries for Multi-Arm Multi-Stage
                        Design
getBound_seamless       Efficacy Boundaries for Phase 2/3 Seamless
                        Design
getCI                   Confidence Interval After Trial Termination
getCI_multiarm          Confidence Interval After Trial Termination for
                        Multi-Arm Multi-Stage Design
getCI_seamless          Confidence Interval After Trial Termination for
                        Phase 2/3 Seamless Design
getCP                   Conditional Power for Generic Group Sequential
                        Design
getCP_multiarm          Conditional Power for Multi-Arm Multi-Stage
                        Design
getCP_seamless          Conditional Power for Phase 2/3 Seamless Design
getDesign               Power and Sample Size for Generic Group
                        Sequential Design
getDesign2              Power and Sample Size for Group Sequential
                        Design With Futility Stopping Under Null
                        Hypothesis
getDesignANOVA          Power and Sample Size for One-Way ANOVA
getDesignANOVAContrast
                        Power and Sample Size for One-Way ANOVA
                        Contrast
getDesignAgreement      Power and Sample Size for Cohen's kappa
getDesignEquiv          Power and Sample Size for Generic Group
                        Sequential Equivalence Design
getDesignFisherExact    Power and Sample Size for Fisher's Exact Test
                        for Two Proportions
getDesignLogistic       Power and Sample Size for Logistic Regression
getDesignMeanDiff       Group Sequential Design for Two-Sample Mean
                        Difference
getDesignMeanDiffCarryover
                        Power and Sample Size for Direct Treatment
                        Effects in Crossover Trials
getDesignMeanDiffCarryoverEquiv
                        Power and Sample Size for Equivalence in Direct
                        Treatment Effects in Crossover Trials
getDesignMeanDiffEquiv
                        Group Sequential Design for Equivalence in
                        Two-Sample Mean Difference
getDesignMeanDiffMMRM   Group Sequential Design for Two-Sample Mean
                        Difference From the MMRM Model
getDesignMeanDiffXO     Group Sequential Design for Mean Difference in
                        2x2 Crossover
getDesignMeanDiffXOEquiv
                        Group Sequential Design for Equivalence in Mean
                        Difference in 2x2 Crossover
getDesignMeanRatio      Group Sequential Design for Two-Sample Mean
                        Ratio
getDesignMeanRatioEquiv
                        Group Sequential Design for Equivalence in
                        Two-Sample Mean Ratio
getDesignMeanRatioXO    Group Sequential Design for Mean Ratio in 2x2
                        Crossover
getDesignMeanRatioXOEquiv
                        Group Sequential Design for Equivalence in Mean
                        Ratio in 2x2 Crossover
getDesignOddsRatio      Group Sequential Design for Two-Sample Odds
                        Ratio
getDesignOddsRatioEquiv
                        Group Sequential Design for Equivalence in
                        Two-Sample Odds Ratio
getDesignOneMean        Group Sequential Design for One-Sample Mean
getDesignOneMultinom    Power and Sample Size for One-Sample
                        Multinomial Response
getDesignOneProportion
                        Group Sequential Design for One-Sample
                        Proportion
getDesignOneRateExact   Power and Sample Size for One-Sample Poisson
                        Rate Exact Test
getDesignOneSlope       Group Sequential Design for One-Sample Slope
getDesignOrderedBinom   Power and Sample Size for Cochran-Armitage
                        Trend Test for Ordered Multi-Sample Binomial
                        Response
getDesignPairedMeanDiff
                        Group Sequential Design for Paired Mean
                        Difference
getDesignPairedMeanDiffEquiv
                        Group Sequential Design for Equivalence in
                        Paired Mean Difference
getDesignPairedMeanRatio
                        Group Sequential Design for Paired Mean Ratio
getDesignPairedMeanRatioEquiv
                        Group Sequential Design for Equivalence in
                        Paired Mean Ratio
getDesignPairedPropMcNemar
                        Group Sequential Design for McNemar's Test for
                        Paired Proportions
getDesignRepeatedANOVA
                        Power and Sample Size for Repeated-Measures
                        ANOVA
getDesignRepeatedANOVAContrast
                        Power and Sample Size for One-Way Repeated
                        Measures ANOVA Contrast
getDesignRiskDiff       Group Sequential Design for Two-Sample Risk
                        Difference
getDesignRiskDiffEquiv
                        Group Sequential Design for Equivalence in
                        Two-Sample Risk Difference
getDesignRiskDiffExact
                        Power and Sample Size for Exact Unconditional
                        Test for Risk Difference
getDesignRiskDiffExactEquiv
                        Power and Sample Size for Exact Unconditional
                        Test for Equivalence in Risk Difference
getDesignRiskRatio      Group Sequential Design for Two-Sample Risk
                        Ratio
getDesignRiskRatioEquiv
                        Group Sequential Design for Equivalence in
                        Two-Sample Risk Ratio
getDesignRiskRatioExact
                        Power and Sample Size for Exact Unconditional
                        Test for Risk Ratio
getDesignRiskRatioExactEquiv
                        Power and Sample Size for Exact Unconditional
                        Test for Equivalence in Risk Ratio
getDesignRiskRatioFM    Group Sequential Design for Two-Sample Risk
                        Ratio Based on the Farrington-Manning Score
                        Test
getDesignSlopeDiff      Group Sequential Design for Two-Sample Slope
                        Difference
getDesignSlopeDiffMMRM
                        Group Sequential Design for Two-Sample Slope
                        Difference From the MMRM Model
getDesignTwoMultinom    Power and Sample Size for Difference in
                        Two-Sample Multinomial Responses
getDesignTwoOrdinal     Power and Sample Size for the Wilcoxon Test for
                        Two-Sample Ordinal Response
getDesignTwoWayANOVA    Power and Sample Size for Two-Way ANOVA
getDesignUnorderedBinom
                        Power and Sample Size for Unordered
                        Multi-Sample Binomial Response
getDesignUnorderedMultinom
                        Power and Sample Size for Unordered
                        Multi-Sample Multinomial Response
getDesignWilcoxon       Group Sequential Design for Two-Sample Wilcoxon
                        Test
getDesign_multiarm      Power and Sample Size for Multi-Arm Multi-Stage
                        Design
getDesign_seamless      Power and Sample Size for Phase 2/3 Seamless
                        Design
getDurationFromNevents
                        Range of Accrual Duration for Target Number of
                        Events
getNeventsFromHazardRatio
                        Required Number of Events Given Hazard Ratio
getRCI                  Repeated Confidence Interval for Group
                        Sequential Design
hazard_pd               Hazard Function for Progressive Disease (PD)
                        Given Correlation Between PD and OS
hazard_sub              Hazard Function for Sub Population
heart                   Stanford heart transplant data from the
                        survival package
hedgesg                 Hedges' g Effect Size
immdef                  Simulated CONCORDE trial data from the rpsftm
                        package
ingots                  The binary data from Cox and Snell (1989, pp.
                        10-11).
kmdiff                  Estimate of Milestone Survival Difference
kmest                   Kaplan-Meier Estimates of Survival Curve
kmpower                 Power for Difference in Milestone Survival
                        Probabilities
kmpower1s               Power for One-Sample Milestone Survival
                        Probability
kmpowerequiv            Power for Equivalence in Milestone Survival
                        Probability Difference
kmsamplesize            Sample Size for Difference in Milestone
                        Survival Probabilities
kmsamplesize1s          Sample Size for One-Sample Milestone Survival
                        Probability
kmsamplesizeequiv       Sample Size for Equivalence in Milestone
                        Survival Probability Difference
kmstat                  Stratified Difference in Milestone Survival
                        Probabilities
liferegr                Parametric Regression Models for Failure Time
                        Data
liver                   The liver data used in SAS PROC PHREG
                        documentation examples.
logisregr               Logistic Regression Models for Binary Data
lrpower                 Log-Rank Test Power
lrpowerequiv            Power for Equivalence in Hazard Ratio
lrsamplesize            Log-Rank Test Sample Size
lrsamplesizeequiv       Sample Size for Equivalence in Hazard Ratio
lrschoenfeld            Schoenfeld Method for Log-Rank Test Sample Size
                        Calculation
lrsim                   Log-Rank Test Simulation
lrsim2e                 Log-Rank Test Simulation for PFS and OS
                        Endpoints
lrsim2e3a               Log-Rank Test Simulation for Two Endpoints (PFS
                        and OS) and Three Arms
lrsim3a                 Log-Rank Test Simulation for Three Arms
lrsim_bmTrtSel          Simulation of a seamless phase II/III design
                        with treatment selection based on a short-term
                        endpoint
lrsim_mcpmod            Log-Rank Test Simulation for MCPMod Design
lrsim_multiarm          Log-Rank Test Simulation for Multi-Arm
                        Multi-Stage Design
lrsim_seamless          Log-Rank Test Simulation for Phase 2/3 Seamless
                        Design
lrsimsub                Log-Rank Test Simulation for Enrichment Design
lrstat                  Number of Subjects Having an Event and Log-Rank
                        Statistics
lrstat-package          Power and Sample Size Calculation for
                        Non-Proportional Hazards and Beyond
lrtest                  Log-Rank Test of Survival Curve Difference
mTPI2Table              mTPI-2 Decision Table
mnOddsRatioCI           Miettinen-Nurminen Score Confidence Interval
                        for Two-Sample Odds Ratio
mnRateDiffCI            Miettinen-Nurminen Score Confidence Interval
                        for Two-Sample Rate Difference
mnRateRatioCI           Miettinen-Nurminen Score Confidence Interval
                        for Two-Sample Rate Ratio
mnRiskDiffCI            Miettinen-Nurminen Score Confidence Interval
                        for Two-Sample Risk Difference
mnRiskRatioCI           Miettinen-Nurminen Score Confidence Interval
                        for Two-Sample Risk Ratio
mtpwexp                 Mean and Variance of Truncated Piecewise
                        Exponential Distribution
natrisk                 Number of Subjects at Risk
nbpower                 Power for Negative Binomial Rate Ratio
nbpower1s               Power for One-Sample Negative Binomial Rate
nbpowerequiv            Power for Equivalence in Negative Binomial Rate
                        Ratio
nbsamplesize            Sample Size for Negative Binomial Rate Ratio
nbsamplesize1s          Sample Size for One-Sample Negative Binomial
                        Rate
nbsamplesizeequiv       Sample Size for Equivalence in Negative
                        Binomial Rate Ratio
nbstat                  Negative Binomial Rate Ratio
nevent                  Number of Subjects Having an Event by Calendar
                        Time
patrisk                 Probability of Being at Risk
pbvnorm                 Distribution Function of the Standard Bivariate
                        Normal
pevent                  Probability of Having an Event
phregr                  Proportional Hazards Regression Models
pmvnormr                Multivariate Normal Probabilities over a
                        Hyperrectangle
ptpwexp                 Distribution Function of Truncated Piecewise
                        Exponential Distribution
pwexpcuts               Piecewise Exponential Approximation to a
                        Survival Distribution
pwexploglik             Profile Log-Likelihood Function for Change
                        Points in Piecewise Exponential Approximation
qmvnormr                Equicoordinate Quantiles of the Multivariate
                        Normal Distribution
qtpwexp                 Quantile Function of Truncated Piecewise
                        Exponential Distribution
rawdata                 A simulated time-to-event data set with 10
                        replications
rdsim_multiarm          Risk Difference Simulation for Multi-Arm
                        Multi-Stage Design
rdsim_seamless          Risk Difference Simulation for Phase 2/3
                        Seamless Design
remlOddsRatio           REML Estimates of Individual Proportions With
                        Specified Odds Ratio
remlRateDiff            REML Estimates of Individual Rates With
                        Specified Rate Difference
remlRateRatio           REML Estimates of Individual Rates With
                        Specified Rate Ratio
remlRiskDiff            REML Estimates of Individual Proportions With
                        Specified Risk difference
remlRiskRatio           REML Estimates of Individual Proportions With
                        Specified Risk Ratio
repeatedPValue          Repeated p-Values for Group Sequential Design
residuals_liferegr      Residuals for Parametric Regression Models for
                        Failure Time Data
residuals_phregr        Residuals for Proportional Hazards Regression
                        Models
riskDiffExactCI         Exact Unconditional Confidence Interval for
                        Risk Difference
riskDiffExactPValue     P-Value for Exact Unconditional Test of Risk
                        Difference
riskRatioExactCI        Exact Unconditional Confidence Interval for
                        Risk Ratio
riskRatioExactPValue    P-Value for Exact Unconditional Test of Risk
                        Ratio
rmdiff                  Estimate of Restricted Mean Survival Time
                        Difference
rmest                   Estimate of Restricted Mean Survival Time
rmpower                 Power for Difference in Restricted Mean
                        Survival Times
rmpower1s               Power for One-Sample Restricted Mean Survival
                        Time
rmpowerequiv            Power for Equivalence in Restricted Mean
                        Survival Time Difference
rmsamplesize            Sample Size for Difference in Restricted Mean
                        Survival Times
rmsamplesize1s          Sample Size for One-Sample Restricted Mean
                        Survival Time
rmsamplesizeequiv       Sample Size for Equivalence in Restricted Mean
                        Survival Time Difference
rmst                    Restricted Mean Survival Time
rmstat                  Stratified Difference in Restricted Mean
                        Survival Times
rtpwexp                 Random Number Generation Function of Truncated
                        Piecewise Exponential Distribution
runShinyApp_lrstat      Run Shiny App
sexagg                  Urinary tract infection data from the logistf
                        package
shilong                 The randomized clinical trial SHIVA data in
                        long format from the ipcwswitch package
simon2stage             Simon's Two-Stage Design
simonBayesAnalysis      Analysis of Simon's Bayesian Basket Trials
simonBayesSim           Simulation of Simon's Bayesian Basket Trials
six                     The repeated measures data from the "Six
                        Cities" study of the health effects of air
                        pollution (Ware et al. 1984).
survQuantile            Brookmeyer-Crowley Confidence Interval for
                        Quantiles of Right-Censored Time-to-Event Data
survfit_phregr          Survival Curve for Proportional Hazards
                        Regression Models
svdcpp                  Singular Value Decomposition of a Matrix
tobin                   Tobin's tobit data from the survival package
updateGraph             Update Graph for Graphical Approaches
zph_phregr              Assess Proportional Hazards Assumption Based on
                        Scaled Schoenfeld Residuals
zstatOddsRatio          Miettinen-Nurminen Score Test Statistic for
                        Two-Sample Odds Ratio
zstatRateDiff           Miettinen-Nurminen Score Test Statistic for
                        Two-Sample Rate Difference
zstatRateRatio          Miettinen-Nurminen Score Test Statistic for
                        Two-Sample Rate Ratio
zstatRiskDiff           Miettinen-Nurminen Score Test Statistic for
                        Two-Sample Risk difference
zstatRiskRatio          Miettinen-Nurminen Score Test Statistic for
                        Two-Sample Risk Ratio
